International Journal of Medicine and Medical Science Research  Vol. 2(4), pp. 048-052, May 2014 ISSN 2331-1819 ©2014 Academe Research Journals

Full Length Research Paper

Subdermal injection of gadolinium with ASIS device in normal humans’ glabella

Li Nguyen^1*, Hanh Nguyen², Thanh Phung³ and Joel Sercarz⁴

¹Automatic Subdermal Injection System, Inc, Westminster, California, Department of Otolaryngology/Head and Neck Surgery,

²Innovative Drug Injection Technology Inc., Newport Beach, California, Department of Anesthesiology,

³Magnolia Medical Imaging Centers, Westminster/Laguna Hills/Orange, California, Department of Radiology,

⁴University of California, Los Angeles, California, Department of Otolaryngology/Head and Neck Surgery

*Corresponding author. E-mail: dr.li.nguyen@asis-inc.com. Tel: 714-453-7857. Fax: 714-775-6256.

Accepted 7 May, 2014

Abstract 

Our previous study which monitored human muscular contractions with an accelerometer found out that the human muscles ran away from the electrical stimuli of an electromagnetic (EMG) needle. Thus, where the needle tip must likely end up every time is just outside of the fascia, or right in the subdermal bloodless space. The current study further explored the above hypothesis by using MRI to monitor the location of gadolinium injections. Using the initial prototype of the ASIS (Automatic Subdermal Injection System) device, gadolinium was successfully injected into the subdermal bloodless space in three out of three normal subjects’ glabellas. This innovation may have a major impact on the healthcare industry because bloodless injections imply longer-lasting medication, which will benefit most, if not all, injectable products.

Key words: Subdermal bloodless space, subdermal injection, injectable EMG needle, electrical stimulation, MRI with gadolinium, muscular contractions.