International Journal of Biology and Biological Sciences Vol. 3(2), pp. 017-022, February 2014 ISSN 2327-3062 ©2014 Academe Research Journals

Full Length Research Paper

Molluscicidal effect of sanguinarine against Oncomelania hupensis snails

Liu Ming¹, Jiang Chonghe^2*, Liu Nianmeng¹, Peng Ling¹, Peng Fei¹, Sun Hui¹, Huang Qiongyao¹ and Yuan Shishan¹

¹Medical College of Hunan Normal University, Changsha 410013, Hunan, China.

²Qingyuan City People’s Hospital of Jinan University, Qingyuan 511518, Guangdong, China.

*Corresponding author. E-mail: chinghe.jiang@gmail.com. Tel. +86-13927625023.

Accepted 21 February, 2014

Abstract

A strong molluscicidal effect of sanguinarine against Oncomelania hupensis snails was demonstrated by immersion test in the present study. A positive relationship between doses, immersion time and the mortality of the snails was exhibited, while the optimal dose and immersion time of application towards the field eradication of snails were suggested. The possible mechanisms of effects were explored by determining the changes in liver aminotransferases (ALT, AST) of the snails and it was revealed that the damage of liver cells was the cause of snail death.

Key words: Alanine aminotransferase, liver, Oncomelania hupensis snail, molluscicide, sanguinarine.