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International Journal of Agricultural Science Research

International Journal of Agricultural Science Research Vol. 4(9), pp. 180-183, August 2015 ISSN 2327-3321 ©2015 Academe Research Journals

 

Full Length Research Paper

Changes in serum electrolyte, creatinine and urea of fresh Citrus limon juice administered to growing rabbits (Oryctolagus cuniculus)

Solomon I.P.1, Oyebadejo S.A.2*, Ukpo E.M.1 and Joseph O.S.3

1Department of Animal Sciences, Faculty of Agriculture, University of Uyo, Akwa-Ibom, Nigeria.

2Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Akwa-Ibom, Nigeria.

3Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Akwa-Ibom, Nigeria.

*Corresponding author. E-mail: samsonoyebadejo@yahoo.com. Tel: +23470332166621.

Accepted 7 September, 2015

Abstract

Changes in serum electrolyte, creatinine and urea of fresh Citrus limon juice administered to growing rabbits were investigated. A total of 24 rabbits, male and female (10-16 weeks), were weighed and distributed into 4 groups. Control, group 1, was administered with normal diets without C. limon juice. 25% C. limon juice was administered to treatment group 2; 50% C. limon juice was administered to treatment group 3; and 75% C. limon juice was administered to treatment group 4. After 5 weeks of administration of juice, animals were weighed and sacrificed. Blood samples were taken into plain bottles and centrifuged, after which serum was collected and sent to laboratory for kidney function assay. Analysis was carried out on electrolyte such as sodium, potassium, creatinine and urea. Result of the sodium and potassium electrolyte was not significant in all the C. limon treatment groups as compared to the control group, while the serum creatinine and urea were extremely significant when compared to the control group at P<0.001. In conclusion, it was revealed that C. limon juice did not pose deleterious or abnormal effects on kidney function parameters of growing rabbits, rather it encouraged adequate and functional clearance.

Key words: Rabbit, kidney, Citrus limon, creatinine, urea, body weight.